New HIV diagnoses in patients with COVID-19: two case reports and a brief literature review.

BACKGROUND: COVID-19 is novel infectious disease with an evolving understanding of its epidemiology and clinical manifestations. Severe cases developed life-threatening complications, such as respiratory failure, shock, and multiple organs dysfunction. Immunocompromised patients often present atypical presentations of viral infected diseases. CASE PRESENTATION: We report newly diagnosed HIV infections in two patients with COVID-19 in China. In our two cases, both patients with elevated IL-6 received Tocilizumab treatment, but did not present obvious therapeutic effect. CONCLUSIONS: These cases highlight possible co-detection of known immunocompromised diseases such as HIV. The two cases we reported stressed the risk of misdiagnosis, especially during the pandemic of an infectious disease and the importance of extended testing even if in immune-compromised condition the immune state may be ignored.

Investigation of the use of goggles by medical staff in Wuhan Huoshenshan Hospital

OBJECTIVE: This study investigated the use of goggles by medical staff in the forefront of combating new coronavirus pneumonia epidemic, in order to explore safer and more effective use of goggles to provide protection for medical staff to protect themselves. METHODS: From Mar. 27, 2020 to Mar. 29, 2020, the Department of Infection Control of Wuhan Huoshenshan Hospital conducted an online questionnaire survey on 310 front-line medical staff who had been working in the hospital for 55 days by using the questionnaire Star software. RESULTS: There were many kinds of goggles in the hospital. The time for medical staff to wear goggles continuously was mainly 5-6 hours (48.71%) and 3-4 hours. Most medical staff believed that goggles without holes on edge were safer (61.94%), and wearing goggles with side holes would increase the risk of eye infection (81.94%). Most medical staff used goggles correctly, they adjusted the tightness of the strap immediately after wearing goggles(71.94%), adjusted the headband to an appropriate tightness (90.97%), and performed anti-fog treatment on the lenses before wearing goggles (99.35%), checked for damage before using goggles (94.19%). Physical discomfort during work was mainly due to fogging of the goggles to block the sight (90.32%), followed by headache (60.97%). The effective duration of fogging of protective eyepieces was mostly 2-4 hours (39.68%) and 4-6 hours (32.26%). Most medical staff believed that wearing lighter (98.71%), softer (94.52%), larger lenses and wider frame (96.45%) goggles was more comfortable. The application of transparent hand sanitizer was the highest recommended anti-fog method for goggles (46.13%), followed by the anti-fog agent method(23.55%). The best anti-fog effect could reach more than 6 hours (4.52%). CONCLUSION: Goggles were the key barrier for protection of new coronary pneumonia infection. Hospitals should attach great importance to the use of safe and comfortable goggles under conditions and anti-fog treatment to improve their own safety and improve work quality and efficiency.